Aneuploidy screening in the first trimester.
نویسنده
چکیده
This article reviews the performance of first trimester screening for chromosomal anomalies using various combinations of ultrasound and maternal serum biochemical modalities. Detection rates in excess of 90% can be routinely achieved for Trisomy 21, Trisomy 13, Trisomy 18 using a combination of fetal nuchal translucency (NT) thickness and maternal serum free ss-hCG and PAPP-A at 11 + 0 to 13 + 6 weeks of gestation.
منابع مشابه
Screening of Fetal Chromosome Aneuploidies in the First and Second Trimester of 125,170 Iranian Pregnant Women
BACKGROUND Aneuploidy is one of the main causes of congenital anomalies, mental and physical disabilities, in newborns. The aim of this study was to determine various chromosomal aneuploidies in the first and second trimester screening of pregnant women, in Iran. METHODS A descriptive retrospective study was conducted on 125,170 pregnant women referred to a major referral medical diagnostic l...
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CPCs are a relatively common finding during the second trimester sonography. when a choroid plexus cyst is identified, the presence of structural malformation and other sonographic markers of aneuploidy should be assessed with a detailed fetal anatomic survey performed by an experienced person. if no other sonographic abnormalities are present, the CPC is considered isolated. given the consider...
متن کاملScreening for early fetal structural anomalies
Improvement of high resolution ultrasound scan equipment, have enabled obstetricians to examine the fetus during first trimester in more detail than ever before. It is established that first trimester ultrasound scan is superior to second trimester scan in determining gestational age, risk assessment for chromosomal aneuploidy and chorionicity in multiple pregnancy1-3. Moreover, first trimester...
متن کاملA survey of prenatal first-trimester aneuploidy screening among Hong Kong specialist obstetricians.
OBJECTIVES To determine the background, qualifications, and certification status of specialists currently performing first trimester screening in Hong Kong, the extent of their participation (and the laboratories they use) in quality assurance programmes, and their willingness to provide follow-up data for auditing purposes. DESIGN Questionnaire survey. SETTING Hong Kong. PARTICIPANTS A s...
متن کاملFirst Trimester Aneuploidy Screening Program for Preeclampsia Prediction in a Portuguese Obstetric Population
Objective. To evaluate the performance of a first trimester aneuploidy screening program for preeclampsia (PE) prediction in a Portuguese obstetric population, when performed under routine clinical conditions. Materials and Methods. Retrospective cohort study of 5672 pregnant women who underwent routine first trimester aneuploidy screening in a Portuguese university hospital from January 2009 t...
متن کاملSecond-trimester genetic sonography after first-trimester combined screening for trisomy 21.
OBJECTIVE The purpose of this study was to evaluate the trisomy 21 screening performance of the first-trimester combined test followed by second-trimester genetic sonography. METHODS This retrospective cohort study included all women with singleton pregnancies undergoing combined screening followed by genetic sonography at 17 to 21 weeks from January 1, 2005, to January 31, 2008. Combined tes...
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ورودعنوان ژورنال:
- American journal of medical genetics. Part C, Seminars in medical genetics
دوره 145C 1 شماره
صفحات -
تاریخ انتشار 2007